Max Planck said in his book, Where Is Science Going? (1932), that physical science rests on two theorems which, by the way, I tend to think are closer to assumptions. The first is: There is a real outer world which exists independently of our act of knowing. The second is: The real outer world is not directly knowable. Then, surprisingly, Plank says “to a certain degree these two statements are mutually contradictory.”
We can draw from this that the physical sciences are always operating under a certain degree of limitation and contradiction in dealing with the outer world, that is, third-person knowledge. Planck then goes on to say on the same page:
"And this fact discloses the presence of an irrational or mystic element which adheres to physical science as to every other branch of human knowledge. The knowable realities of nature cannot be exhaustively discovered by any branch of science. This means that science is never in a position completely and exhaustively to explain the problems it has to face. We see in all modern scientific advances that the solution of one problem only unveils the mystery of another. Each hilltop that we reach discloses to us another hilltop beyond. We must accept this as a hard and fast irrefutable fact. And we cannot remove this fact by trying to fall back upon a basis which would restrict the scope of science from the very start merely to the description of sensory experiences. The aim of science is something more. It is an incessant struggle towards a goal which can never be reached. Because the goal is of its very nature unattainable. It is something that is essentially metaphysical and as such is always again and again beyond each achievement." (Emphasis is mine.)
So, the goal that the physical sciences aim for by its very nature is unattainable. But this is not to say or to suggest that the inner goal of self-knowing is also unattainable. It may well be attainable whereas complete knowledge of the outer world is just another hilltop that discloses still more hilltops—like in the example of galaxies when there, at first, was only our Milky Way, which was the sum of the universe around 1900. And now there are at least one hundred billion galaxies in the observable universe beyond our galaxy!
Yet, from the standpoint of Buddhism this is nothing to be in awe of. For all that we could ever imagine or see, which is conditioned, is composed from the unconditioned (a term that has many other names). Realizing the unconditioned which is nirvana is awakening to the glorious realization that all is but an expression of the One Mind. I would only add one more thing. Absolute science is taught by Buddhism which includes third-person knowledge which is rooted, fundamentally, in first-person knowledge of what is the substance or essence of our thoughts.