There is no liberation without a setting free of that which was imprisoned. In Buddhism, realizing our Buddha-nature is accomplished by removing that which is empty and illusory which makes our Buddha-nature seem absent or hidden but worse, makes what is empty and illusory seem real—too real.
In this inverted state (viparyāsa) we cling to the unreal and reject the real. As a consequence, it becomes difficult, if not impossible for us to seek and to find the pure Mind, i.e., our Buddha-nature insofar as our pure Mind is entirely covered over by thought-constructions, hidden inside an illusory body (one we believe to be our default self).
Our proper Buddhist education has to begin with reversing our long and deeply held deluded view of what we believe to be reality because, to be frank, it is totally wrong. It’s like believing the sun orbits the earth, refusing to believe otherwise. Is this a kind of delusion that begins from birth? The answer is yes, it is a delusion insofar as it is held with a very strong, unconscious conviction despite the evidence going counter to it such as the fact that things are always changing being in this regard mere appearances in which nothing is substantial.
This is the fact that those new to Buddhism must face. It is a fact that they can nod their heads to but never actually live as if this is reality. Nevertheless, to reiterate, all things are only appearances or māyā being a kind of duplicity. They are not actually real—they are only relatively real insofar as we value and cling to them treating and utilizing them as being the only reality for a small period of time. As long as we continue on this wrong track we remain deluded. An interesting aside, Karl Jaspers proposed 3 criteria for delusional beliefs in 1913: 1) the fixity of belief; 2) incorrigibility; 3) impossibility (e.g., Muhammad didn't plunder or have anyone killed).
The third or 'impossibility' is our acceptance that the world we live and die in is the only reality when it is not. The further science looks within, so the speak, like the Buddha of old, it sees a much different reality. It is Mind which is the matrix of all things.